5 Berberine Benefits, Facts and Evidence

What is it?

> Scientific/Other Names: Berberine hydrochloride
> Supplement Type: Alkaloid
> Taken as: Capsule, tablet, extract

Berberine is a bioactive compound found naturally in many plants. It has been used in traditional Chinese and Ayurvedic medicine for centuries. Contemporary research suggests that berberine benefits include support for weight loss, blood sugar regulation, and protection against several chronic conditions.  Its powerful ability to reduce blood sugar, may rival some anti-diabetic drugs.

Note – Berberine HCL is the hydrochloride salt form, which enhances its absorption and bioavailability in humans.

Berberine HCL is thought to:

• Improve insulin sensitivity and regulate blood sugar levels
• Support cardiovascular health
• Aid in weight loss
• Reduce cholesterol levels
• Possess antimicrobial properties

Berberine is believed to activate AMP-activated protein kinase (AMPK), an enzyme that plays a key role in regulating metabolism. Activation of AMPK can improve insulin sensitivity and promote glucose uptake into cells, which helps in blood sugar regulation.
Berberine also appears to influence lipid metabolism, which may help lower cholesterol levels.
Additionally, its antimicrobial properties make it useful against various bacterial, viral, and fungal infections.

_{See our guide on Supplement Mechanisms}

Many studies show Berberine can significantly lower blood sugar levels which can assist in appetite suppression

> Clinical Trials: Several studies, mostly human trials
> Test Size: Medium (50-250 participants)
> Results: Research suggests that berberine can significantly improve blood sugar control in people with type 2 diabetes. A 2008 study of 116 people with diabetes, taking 1 gram of berberine per day lowered fasting blood sugar by 20%
Other studies have also indicated that Berberine may help lower cholesterol levels.
Some studies indicate potential benefits for weight loss and cardiovascular health. However, more extensive research is needed to fully confirm these effects.
_{See our guide on trial sizes.}

900-2,000mg daily

The effective dose of berberine is 900-2,000mg a day, divided into three to four doses.

So, does it work?

• Generally considered safe at recommended doses
• Possible side effects: gastrointestinal issues such as constipation, diarrhea, and stomach pain
• Long-term safety data is limited, so prolonged use should be monitored by a healthcare provider
• May interact with other medications, including those for diabetes and high blood pressure, so consultation with a healthcare provider is recommended

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1. The effects of berberine supplementation on cardiovascular risk factors in adults: A systematic review and dose-response meta-analysis.
2. Treatment of type 2 diabetes and dyslipidemia with the natural plant alkaloid berberine
3. Berberine in the treatment of type 2 diabetes mellitus: a systemic review and meta-analysis
4. Efficacy of Berberine in Patients with Non-Alcoholic Fatty Liver Disease